Genetically at Risk for Alzheimer’s Disease? DO THIS…

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I’d like to talk about the genetic aspects of Alzheimer’s disease unfortunately Alzheimer’s has become a massive problem worldwide and it touches 54 of the population so sooner or later you are going to run into this topic and I want to give you some very important information on prevention as well as what you can do if you have it yourself or a friend or family member has this condition but I want to talk about a genetic tendency for Alzheimer’s okay if you get your genes tested which I’m not necessarily recommending you do or you don’t I just want to educate you on a very specific common Gene that shows up with 20 of the population and this involves a variation in a gene called apoe but basically this molecule helps you transport uh cholesterol into the brain now it does a lot of other things but the area that I’m going to focus on is what it does in the brain it transports cholesterol into the brain okay and helps maintain cholesterol levels as well as clear as cholesterol out of the brain so you can think about apoe is really a shuttle or a little carrier boat that transports cholesterol and there’s three variations that you could potentially have the first one is apoe two okay and then you have an apoe tree and the next one is a poe4 okay now I guess the best way to help you understand this simply is that APO E2 would be comparable to ordering something through Amazon you know getting it Prime and you get it overnight so it’s a fast delivery of a certain product if you have a Poe II you’re going to be able to transport cholesterol very very fast and you’re going to be able to clear it very quickly as well and about five percent of the population has this variation apoe two and they will rarely ever get Alzheimer’s so now apoe three well that would be like you know using like FedEx or UPS pretty decent delivery not too fast not too slow probably is going to arrive in three days maybe a week and so if you have the variation which 75 percent of the population has you have a normal function of that Gene and so you’re not really at risk of getting Alzheimer’s but the real problem comes in with the next variation called apoe4 if you have this variation in your DNA this would be equivalent to using the regular post office during the holidays it’s going to be extremely slow and you may have some issues twenty percent of the population has this apoe4 fraction and they’re at risk for getting Alzheimer’s okay especially if it’s late stage Alzheimer’s and now you’re probably asking like what does cholesterol have to do with Alzheimer’s right well did you realize that your brain is 25 made up of cholesterol in fact your brain cells make cholesterol uh this cholesterol is needed for many many different things and I’m not just talking about cholesterol I’m talking about other types of lipids as well so your brain it’s like 65 fat and it uses a lot of cholesterol to make uh its coating or its myelin sheath it uses triglycerides for energy it needs cholesterol for the synapses to work to allow it to adapt to stress and it needs it desperately to be able to repair and what’s very unique about Alzheimer’s is that if we don’t have enough cholesterol that’s driven into the neuron okay you will start losing synapses especially in certain parts of your brain that involve memory learning concentration like the hippocampus and even the frontal cortex and so really you have a cholesterol deficiency in your neurons now this is pretty interesting because we always think about cholesterol being a really bad thing but in this case it’s a very good thing if you have enough cholesterol but at the same time there’s some other things going on because remember I mentioned that this protein also clears cholesterol from the brain so we have this situation where we have a deficiency of cholesterol which is basically killing off the neurons at the same time have this toxicity of a lack of clearing of cholesterol so it’s called lipotoxicity which comes with a lot of issues including resultant plaquing you increase this lip of toxicity by a factor of 4X now your brain is now going to do something to compensate for this so it’s going to force the brain to switch to glucose metabolism but the problem is this Gene also blocks the ability to absorb glucose too now since glucose is blocked really what’s happening is we’re getting a lack of fuel to the neurons the absolute best thing you can do is start the ketogenic diet where you lower carbs you start doing intermittent fasting and ketones bypass this problem and feed the neurons directly so basically we have a situation we have low cholesterol trying to switch to glucose but can’t and so we really have a problem with lack of material to build the membranes as well as a lack of fuel to feed neurons now the reason why this is associated with late stage Alzheimer’s is because just Aging in general causes you to lose the ability to utilize the cholesterol too so it’s kind of like a compounding thing where this variation cause is a low cholesterol but then aging makes it worse and this is why if you have this Gene problem it could potentially kick in around 60 to 65 years old or a little bit later the other really interesting thing about cholesterol in general is that when someone takes a lipophilic Statin their risk of dementia goes way up why do you think that is well because statins block cholesterol and when someone takes a Statin they really have a problem with certain parts of the brain that are involved with Alzheimer’s so in one study they found that if you’re on a lipophilic Statin your chances of getting Alzheimer’s doubles realize this because someone has this genetic problem there is something you can do about it because there’s something called epigenetics which are those actions that are related to Lifestyle diet environment that you can suppress this Gene so it doesn’t become active it doesn’t become a problem and things can work correctly the first thing is to avoid alcohol alcohol is a very potent effect worsening this problem and kicking in this Gene so it’s more expressed and there’s more problems number two to avoid smoking that has a huge impact on this Gene as well as well as secondhand smoking number three exercise I’m talking about consistent regular exercise as a significant effect on this Gene it can greatly greatly help you you know our bodies are designed to exercise and move and if we’re not exercising all sorts of problems occur but the exercise alone as one factor can help decrease atrophy of the hippocampus in your brain which is intimately involved in memory and concentration and learning exercise increases blood flow to the brain directly it also increases something called the bdnf the brain derived neurotrophic factor which is similar to miracle grow for your brain it helps you grow new brain cells and exercise is a potent stimulus to increase this bdnf most of the population has insulin resistance and exercise is a great way to improve that situation and what’s interesting about that is when someone has plaquing in the brain because they have Alzheimer’s the plaquing can insert into your insulin receptors and actually cause insulin resistance in the brain and there’s a huge association between insulin resistance and dementia and Alzheimer’s so anything you can do to improve insulin is a very very good thing and I’m going to mention just two things right now going a low carb diet fasting taking a natural form of vitamin B1 and taking apple cider vinegar in your water those things are very very significant and lastly exercise can help reduce inflammation in your brain the next thing I want to mention is omega-3 fatty acids that can greatly help you one of the problems with omega-3 fatty acids especially if you’re very very deficient and you have a lot of inflammation it could take quite some