Leptin Resistance is Behind a Weakened Immune System

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hey everyone today i have another special guest ivor cummins is here welcome i iver how you doing hey eric great to see you again good seeing you too so uh ivor has been to both of my summits the keto summit and he always has incredible information he’s an expert in cholesterol cardiovascular health and also calcium in the arteries which he is going to be talking about but so so there’s also a relationship between um the risk factors for this uh situation that we’re in right now uh maybe you wanna mention that or talk about that yeah eric i’ve actually the last few weeks i’ve kind of diverted my attention from cardiovascular and metabolic and all the usual stuff to this big issue and um partly because i’m fascinated it’s it’s an absolutely fascinating challenge and tragic one for many people of course we won’t forget that uh but also because the world out there is so focused on it that right now is probably not the perfect time to be doing my usual stuff because there’s such a hunger to know more about this and i’m very well positioned to decode the science for people so i’ve been doing a lot of work on it and yeah as you just said i mean the risk factors for corona it’s so striking hypertension cardiovascular disease copd all the classic signs of insulin resistance or leptin resistance syndrome which is an epidemic in our modern world and we saw that from the china data at the very start i picked up on it way back and i said wow this is hitting the very people that the heart disease hits right it’s the same people the same metabolic issues fascinating fascinating um you know for those people that don’t know um see you’re an engineer and i assume like i think electrical engineer but no it’s a biochemical engineer biochemical yeah which is a completely different uh animal because you have to know chemistry and biology and all this stuff so you can read the research and understand it and pull strings and which is very very interesting so i just want to make that note which is important yeah you do need the expertise now that was my primary degree and then i spent a couple of decades slightly different industries but you never really forget and interestingly in college doing biochemical the biochemistry classes in the in the various years they were the ones that were my most favorites they could because they were fascinating you know we did genetics we did all of the citric acid cycle all metabolism and we actually did a lot of that stuff fascinating but then my my job i didn’t really use it much but many years later of course eight years ago when i had poor blood test results i had to go back in and research and answer the questions so it’s been great to go back to it yeah oh that’s great yeah so the uh risk factor for um the colbit you have um uh high blood pressure is a tablet list cardiovascular obesity diabetes insulin resistance i mean that all just comes down to this insulin resistance thing it does exactly and copd as well but that’s largely connected too so the orthodoxy or the establishment is seeing these as all these different things but of course you and i know they all go back to the same roots of insulin resistance and maybe a little thing to add as well is leptin resistance so way back at the start of this whole issue i interviewed dr ron rosedale he’s kind of a genius i think and he’s stuck in india where he works to help with their diabetes epidemic and obesity epidemic and he was the guy who actually originally 25 30 years ago he discovered the crucial nature of insulin and measuring insulin and leptin another hormone and he actually worked out originally that of course the atkins diet the keto diet is correct a no-brainer because you keep your insulin and leptin low and you keep your glucose low and that is the best thing for long life and health but he went through with me in a full hour-long podcast how leptin resistance for which is kind of the same as insulin resistant to anyone listening leptin resistance is the kind of core part of a poor immune function and without going into detail he went through how leptin not only when your leptin signaling is disrupted when you’re insulin resistant which are leptin signaling being disruptive completely undermines your immune system and all of the processes that cause the issues with this virus and leptin is even actively involved in the immune system it’s part of your immune response and if you’ve disrupted that signaling because you’ve become overweight and insulin resistant leptin cannot do its immune function job correctly so again without going into the weeds it’s so intimately connected now aren’t people um they’re associating leptin with hunger appetite right yeah so leptin is a fat cell hormone but it’s also excreted and used in many other places but generally leptin is part of your appetite control system and if you eat and your fat cells you know expand the leptin signal tells you long term that you’re getting enough food and it reduces your appetite the tragedy is if you become leptin resistant the system doesn’t hear the signal anymore and then the appetite is not controlled so it’s very like insulin resistance but also there’s one special challenge which is a corner case very interesting that sometimes people who are middle aged particularly females when they actually lose a lot of weight and they lose a lot of fat cells they become low leptin which is very healthy low leptin is healthy but sometimes the lower leptin tends to trigger a little bit of appetite and that and that can make it hard for people who’ve lost weight who hit a plateau you know they’re lower leptin now and it tends to keep the appetite triggered so you just need to learn to understand that and and overcome it but yeah now the things that uh correct or improve insulin resistance they’re the same things that improve the leptin absolutely for the person in the street so to speak the beauty of it is if you want to get into the science that’s great but leptin resistance insulin resistance there’s no real separation in terms of what you do to stop them happening or what you do to make them worse they’re really tight at the at the hip now is there any relationship between um the metabolic syndrome issues and uh ace2 inhibitors ah the ace2 inhibitors yeah so dr rosedale actually went through that in some detail a lot of people think that maybe the ace2 inhibitors the drugs are causing maybe the higher susceptibility and what dr rosedale pointed out was that’s not necessarily the case that your ace receptors they’re actually proteins just because there’s more of them doesn’t mean necessarily that you’ll draw in more virus there were studies he quoted so i think that it’s a bit simplistic to say that the drugs for hypertension are causing more ace receptors and bringing in the virus i think what is probably more likely is the kinds of people who are on those drugs they suffer from insulin and leptin resistance right they’re given to people with hypertension and most hypertension is undiagnosed insulin resistance so the drugs associate the blood pressure drugs associate with worse outcomes but but it’s really confounded i think it’s just that they give the drugs to diabetics overwhelmingly and people with hypertension and it’s really those people’s metabolic problems that’s really linking to the worse outcomes and and the challenges wow so when you talk to this uh doctor did he uh mention the susceptibility goes up when you um for um when you have leptin resistance and then the immune system goes down and then the virus could potentially take over is that was that the connection or yeah absolutely that uh leptin resistance like insulin resistance it’s like a smelly room you no longer kind of smell after a while in the smelly room and when your body is subjected to high leptin and high insulin you can